Additional file 4: of Herd immunity alters the conditions for performing dose schedule comparisons: an individual-based model of pneumococcal carriage

Figure S3. Relative Vaccine Efficacies of Goldblatt et al. PCV13 in a Simulated Trial. Relative vaccine efficacies during a vaccine trial simulated under assumptions of less divergence between the efficacies of different dose schedules. (a) Relative VE determined using prevalences. (b) Relative VE determined using prevalence odds. In both sub-figures, the “calculated” relative VE was determined from the initial VE parameters of the simulation according to the formula: Relative VE = 1 – (1 – VEintervention)/(1 – VEreference). (JPG 332 kb