Figure S5. Heatmap showing expression of all differentially expressed and downregulated genes in both TET2-KOs as compared to RWPE-1 cells. Expression gradient bar indicates gene-normalized expression levels, ranging from highest (yellow) to lowest (dark blue). Heatmap was generated via unsupervised clustering and clusters RWPE-1 cells separately from knockouts. (TIF 29524 kb
Table S4. Expression of candidate genes significantly associated with ERG fusion status. (XLSX 18 kb
Table S7. Clinicopathological characteristics of prostate tumor tissues used for methylation analysi...
Table S1. Primer and probe sequences used for CRISPR verification and methylation-specific qPCR. (XL...
Figure S6. Heatmap showing expression of 780 genes which exhibited significant expression alteration...
Figure S10. Heatmap showing methylation of seven candidate genes for all tumor (n = 428) and normal ...
Table S2. Genes exhibiting both significantly increased promoter methylation and significantly lower...
Figure S7. Pathway enrichment analysis of genes losing expression in CRISPR-TET2 knockout cells. Vis...
Table S3. Characteristics of the 61 genes exhibiting significantly increased promoter methylation an...
Table S6. Analysis of candidate gene probes in an independent methylation array dataset (GSE73549). ...
Figure S3. Overexposed Western blot for TET2 protein in parental RWPE-1 and TET2-KO cells. Overexpos...
Figure S9. Methylation array probe locations on candidate genes with respect to the TET2-knockout me...
Figure S1. CRISPR-TET2 guide RNA targets the first coding exon of TET2. Arrows indicate the CRISPR t...
Figure S13. Diagnostic enrichment plot of MBD-Seq samples from TET2-KO cells as compared to input co...
Table S5. Association of candidate gene probe methylation with ERG fusion status. (XLSX 19 kb
Figure S14. Multidimensional scaling (MDS) plot depicting Euclidean distances (similarities) between...
Table S4. Expression of candidate genes significantly associated with ERG fusion status. (XLSX 18 kb
Table S7. Clinicopathological characteristics of prostate tumor tissues used for methylation analysi...
Table S1. Primer and probe sequences used for CRISPR verification and methylation-specific qPCR. (XL...
Figure S6. Heatmap showing expression of 780 genes which exhibited significant expression alteration...
Figure S10. Heatmap showing methylation of seven candidate genes for all tumor (n = 428) and normal ...
Table S2. Genes exhibiting both significantly increased promoter methylation and significantly lower...
Figure S7. Pathway enrichment analysis of genes losing expression in CRISPR-TET2 knockout cells. Vis...
Table S3. Characteristics of the 61 genes exhibiting significantly increased promoter methylation an...
Table S6. Analysis of candidate gene probes in an independent methylation array dataset (GSE73549). ...
Figure S3. Overexposed Western blot for TET2 protein in parental RWPE-1 and TET2-KO cells. Overexpos...
Figure S9. Methylation array probe locations on candidate genes with respect to the TET2-knockout me...
Figure S1. CRISPR-TET2 guide RNA targets the first coding exon of TET2. Arrows indicate the CRISPR t...
Figure S13. Diagnostic enrichment plot of MBD-Seq samples from TET2-KO cells as compared to input co...
Table S5. Association of candidate gene probe methylation with ERG fusion status. (XLSX 19 kb
Figure S14. Multidimensional scaling (MDS) plot depicting Euclidean distances (similarities) between...
Table S4. Expression of candidate genes significantly associated with ERG fusion status. (XLSX 18 kb
Table S7. Clinicopathological characteristics of prostate tumor tissues used for methylation analysi...
Table S1. Primer and probe sequences used for CRISPR verification and methylation-specific qPCR. (XL...