Pharmacokinetic assessment of the monepantel plus oxfendazole combined administration in dairy cows
- Ballent, Mariana
- Viviani, Paula
- Imperiale, Fernanda Andrea
- Dominguez, Maria Paula
- Halwachs, S.
- Mahnke, H.
- Honscha, W.
- Lanusse, Carlos Edmundo
- Virkel, Guillermo Leon
- Lifschitz, Adrian Luis
DOIAbstract
Monepantel (MNP) is a novel anthelmintic compound launched into the veterinary pharmaceutical market. MNP is not licenced for use in dairy animals due to the prolonged elimination of its metabolite monepantel sulphone (MNPSO2) into milk. The goal of this study was to evaluate the presence of potential in vivo drug-drug interactions affecting the pattern of milk excretion after the coadministration of the anthelmintics MNP and oxfendazole (OFZ) to lactating dairy cows. The concentrations of both parent drugs and their metabolites were measured in plasma and milk samples by HPLC. MNPSO2 was the main metabolite recovered from plasma and milk after oral administration of MNP. A high distribution of MNPSO2 into milk was observed. The milk-to-pla...
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