Scotopic ERG recordings from saline-treated and TIMP1-treated <i>rd1</i> retinas.

<p>Representative b-wave (A) from saline-treated and TIMP1-treated retinas is shown in Fig 4. In P30 and P45, the b-wave amplitudes of TIMP1-treated <i>rd1</i> retinas were significantly higher than those of saline-treated <i>rd1</i> retinas but not to the degree of normal retina (**** P<0.0001, ** P = 0.004, * P = 0.03). Representative waveforms of the scotopic ERG response from each group were generated. Rhodopsin immunoreactivity was in the cell bodies and some processes of rods in saline-treated <i>rd1</i> retinas. In contrast, rhodopsin immunoreactivity was in some segments (arrowheads), cell bodies, and processes of rods in TIMP1-treated <i>rd1</i> retinas (C, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197322#pone.0197322.s002" target="_blank">S2 Fig</a>). The inset shows higher magnification of b-wave (arrow) of both saline-treated and TIMP1-treated P30 retinas. Data represents mean ± SEM, **** P<0.0001, ** P = 0.004, * P = 0.03; P, postnatal. Scale bar = 10 μm.