<p>(<b>a</b>) Graphs show performance of 12-week old mice of the indicated genotypes on an accelerating Rotarod, showing the mean±SEM speed (rpm) at which they fell off, on three successive days of testing (n = 12 wild-type[WT], 14 Dp(16)1Yey; 11 WT, 12 Dp(17)1Yey; 11 WT, 17 Dp(10)1Yey; 6 WT, 5 Dp(16)1Yey, 6 Dp(16)1Yey/Dp(17)1Yey, 6 Dp(16)1Yey/Dp(10)1Yey, 10 Dp(17)1Yey/Dp(10)1Yey, 6 Dp(16)1Yey/Dp(17)1Yey/ Dp(10)1Yey; 13 WT, 15 Dp9Tyb; 9 WT, 12 Dp2Tyb; 9 WT, 18 Dp3Tyb; 15 WT, 15 Ts1Rhr; 15 WT, 15 Dp4Tyb; 15 WT, 20 Dp5Tyb; 15 WT, 15 Dp6Tyb; 36 WT, 18 Ts1Rhr, 21 Ts1Rhr/<i>Dyrk1a</i><sup>+/-</sup>; 10 WT, 5 Dp(16)1Yey, 10 Dp(16)1Yey/<i>Dyrk1a</i><sup>+/-</sup>). Data analyzed with 2-way ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001; ns, not signif...
<p>(a) Time course of mice behavior tests: rotarod performance test, footprints patterns analysis an...
<p>(A) Gait analysis. <i>Left panel</i>: Mean fore stride and hind stride distance (± SEM) per cm tr...
<p>Treadmill exercise test performed on 2 mo old WT, <i>mdx</i> and <i>mdx/θ<sup>−/−</sup></i> mice ...
<p>Diagram on left shows Hsa21 indicating short and long arms separated by the centromere (oval), ba...
<p>Mean values ± SEM of the latency to fall from the rotarod at different constant speeds (<b>a</b>)...
<p>(A) The locomotor activity after various doses of MPH. Each mouse was placed in a locomotor activ...
<p><i>Irp2<sup>−/−</sup></i> mice display reduced horizontal locomotor activity (total distance trav...
<p>PGC-1α <sup>+/+</sup>, <sup>+/−</sup>, and <sup>−/−</sup> littermates were assessed for motor coo...
<p>(<b>a</b>-<b>e</b>) Analysis of Tc1 mice and WT littermate controls at the indicated ages (n = 4 ...
<p>(A) <i>Elfn1<sup>+/−</sup></i> mice completed a wire hang trial with a success rate of 91.67% and...
<p>A–D. <i>Analysis of gait parameters by using the DigiGait apparatus.</i> Analysis of swing durati...
Changes in (A) rotatrod performance, (B) support base, (C) stride, and (D) support ratio over time i...
<p><i>HdhQ111</i>/+ and Hdh+/+ mice at 46 weeks of age were tested on an automated CatWalk system (A...
Deficits in motor function are debilitating features in disorders affecting neurological, neuromuscu...
(B) Mean stride lengths (in millimeters) of the mice in A show that the abnormal gait seen in N171-8...
<p>(a) Time course of mice behavior tests: rotarod performance test, footprints patterns analysis an...
<p>(A) Gait analysis. <i>Left panel</i>: Mean fore stride and hind stride distance (± SEM) per cm tr...
<p>Treadmill exercise test performed on 2 mo old WT, <i>mdx</i> and <i>mdx/θ<sup>−/−</sup></i> mice ...
<p>Diagram on left shows Hsa21 indicating short and long arms separated by the centromere (oval), ba...
<p>Mean values ± SEM of the latency to fall from the rotarod at different constant speeds (<b>a</b>)...
<p>(A) The locomotor activity after various doses of MPH. Each mouse was placed in a locomotor activ...
<p><i>Irp2<sup>−/−</sup></i> mice display reduced horizontal locomotor activity (total distance trav...
<p>PGC-1α <sup>+/+</sup>, <sup>+/−</sup>, and <sup>−/−</sup> littermates were assessed for motor coo...
<p>(<b>a</b>-<b>e</b>) Analysis of Tc1 mice and WT littermate controls at the indicated ages (n = 4 ...
<p>(A) <i>Elfn1<sup>+/−</sup></i> mice completed a wire hang trial with a success rate of 91.67% and...
<p>A–D. <i>Analysis of gait parameters by using the DigiGait apparatus.</i> Analysis of swing durati...
Changes in (A) rotatrod performance, (B) support base, (C) stride, and (D) support ratio over time i...
<p><i>HdhQ111</i>/+ and Hdh+/+ mice at 46 weeks of age were tested on an automated CatWalk system (A...
Deficits in motor function are debilitating features in disorders affecting neurological, neuromuscu...
(B) Mean stride lengths (in millimeters) of the mice in A show that the abnormal gait seen in N171-8...
<p>(a) Time course of mice behavior tests: rotarod performance test, footprints patterns analysis an...
<p>(A) Gait analysis. <i>Left panel</i>: Mean fore stride and hind stride distance (± SEM) per cm tr...
<p>Treadmill exercise test performed on 2 mo old WT, <i>mdx</i> and <i>mdx/θ<sup>−/−</sup></i> mice ...