Atorvastatin decreases survival of sensitive but not resistant breast cancer cells.

<p>(A-L) MDA-MB-231 or (M-X) MCF-7 breast cancer cells were treated with 0.01% DMSO (untx, A-D and M-P), 5μM atorvastatin (5uM Atorv, E-H and Q-T), or 1μM Doxorubicin (1uM Doxo, I-L and U-X) for 0 hours, 24 hours, 48 hours, or 72 hours in the presence of 1μg/mL propidium iodide. Cells were imaged using an inverted microscope to detect propidium iodide (red) and look at cell morphology and density using phase contrast microscopy. Scale bar = 200μm. All data are representative of at least three independent experiments.