Lipophilic atorvastatin is more effective at suppressing cancer cell growth than hydrophilic rosuvastatin or pravastatin.

<p>Dose response curves for (A) MCF-7 RFP, (B) MDA-MB-231 RFP, (C) MDA-MB-231 RFP/Ecad, (D) DU-145 RFP, (E) SF-295, and (F) MDA-MB-435 cancer cells when cultured with atorvastatin (red), rosuvastatin (green), or pravastatin (blue) for 72 hours. Cell number was determined by crystal violet staining. Sigmoidal curves were fit to the dose response data and (G) IC₅₀ values of atorvastatin and rosuvastatin in each cell line were extrapolated. (H) Pharmacologic parameters of atorvastatin, rosuvastatin, and pravastatin as found in the literature [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197422#pone.0197422.ref024" target="_blank">24</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197422#pone.0197422.ref031" target="_blank">31</a>]. All data are representative of at least three independent experiments.