Influence of PKC pathway on titan-like cell formation.

<p>The influence of the PKC pathway was evaluated by its inhibition with three different agents: Bisindolylmaleimide I (A), Calphostin C (B), Staurosporine (C). Genestein, a tyrosine kinase inhibitor, was used as control (D). The experiments in A, B and D were performed the same days, so they share the same control. However, for clarity, the graphs corresponding to each inhibitor have been separated. The experiments were repeated on three days, and the data from the three experiments is plotted. Cells of the H99 strain were incubated with these different agents overnight in TCM at 37°C with 5% CO₂ without shaking and cell body size was measured. The asterisks indicate statistical significant differences.