The effect of kinase inhibitors on B cell and PBMC viability.

<p>The viability curves of B cells and PBMCs after four days of incubation with different concentrations of each inhibitor are depicted. Treatment of cells with DMSO served as control. (A–D): Percent survival of LCL-WT (open circles), LCL-flag-LMP1 (solid rectangles), DG75 (solid triangles) and PBMCs (asterisks) treated with inhibitor PP2 (A), compound 5 (B), CI-1040 (C) or PD 198306 (D). (E–H): BL41-B95-8 (open circles) and BL41 cell line (solid rectangles) percent survival after treatment with inhibitor PP2 (E), compound 5 (F), CI-1040 (G) and PD 198306(H). The results are the means ± SEM from three independent experiments. Statistical analysis was performed using Student's <i>t</i> test. Statistically significant differences (p<0.05) in viability between each LCL and DG75 as well as PBMCs (panels A to D), or between BL41-B95-8 and BL41 cell lines (panels E to H) are shown by *.