Additional file 1: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Additional file 6: Figure S4. of Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Zihang Xu (4028183)
Fei Zhang (85787)
Chao Bai (4428472)
Chao Yao (3745564)
Hairong Zhong (4428475)
Chunpu Zou (4428478)
Xiao Chen (260187)

September 2017

After pretreated with 5 mM NAC for 2 h, cells were treated with or without 20 μM Sophoridine for ind...

Promoting Effects of Sanguinarine on Apoptotic Gene Expression in Human Neuroblastoma Cells

AKTAŞ, SAFİYE
Ercetin, Pinar
ALTUN, ZEKİYE SULTAN
Cecen, Emre
Olgun, Nur

January 2014

Neuroblastoma is the most common extracranial solid tumor in children. Approximately half of the aff...

Additional file 2: Figure S1. of Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

Timothy Budden (441738)
Andre van der Westhuizen (4802022)
Nikola Bowden (3534809)

January 2018

Representative bright-field microscopy images of senescence associated β-galactosidase staining in a...

Additional file 2: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S2. Apoptosis was detected in HCT116 cells treated with sanguinarine. Cells were treated with...

Additional file 3: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S3. Apoptotic cells were significantly increased by sanguinarine treatment. Indicated CRC cel...

Additional file 5: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S5. Change of the mitochondrial membrane potential (MMP) in SW480 cells by sanguinarine. Cell...

Additional file 4: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S4. Z-VAD-fmk inhibited sanguinarine-induced apoptosis in CRC cells. After treatment with the...

Additional file 8: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S8. HCT116 WT and HCT116 Bax −/− cells were treated with sanguinarine for 12 h. RNA was extra...

Induction of apoptosis by sanguinarine in the bladder cancer cells.

Min Ho Han (586092)
Cheol Park (358509)
Cheng-Yun Jin (586093)
Gi-Young Kim (137710)
Young-Chae Chang (436164)
Sung-Kwon Moon (137717)
Wun-Jae Kim (81624)
Yung Hyun Choi (132605)

May 2013

<p>(A) The cells were incubated with 1.5 µM sanguinarine for 24 h and then stained with DAPI. The st...

Additional file 6: of The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivo

Pedro Cruz-Nova (5919875)
Michael Schnoor (419644)
José Correa-Basurto (472076)
Martiniano Bello (152281)
Paola Briseño-Diaz (5919893)
Arturo Rojo-Domínguez (5919902)
Carlos Ortiz-Mendoza (5919911)
Jorge Guerrero-Aguirre (5919917)
Francisco García-Vázquez (5919923)
Rosaura Hernández-Rivas (510505)
María del Rocío Thompson-Bonilla (3342392)
Miguel Vargas (85521)

November 2018

Figure S3. TUNEL staining of xenograft tumors. (A) Apoptotic cells appear green and nuclei were stai...

Additional file 1: Figure S1. of ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells

Reshma Thamkachy (3767449)
Rohith Kumar (465288)
K. Rajasekharan (3767446)
Suparna Sengupta (465292)

March 2016

Comparison of apoptosis in HCT116 and HCT116 p53 −/− cells treated with vinblastine : Cells were tre...

Additional file 4: Figure S3. of Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors

Alicja Pawlak (3453380)
Ewa Ziolo (3453386)
Anna Fiedorowicz (3453383)
Klaudyna Fidyt (3453374)
Leon Strzadala (3453377)
Wojciech Kalas (3453371)

November 2016

Combinatorial treatments increase CRC cell apoptosis. Annexin V-FITC/PI-double staining of HCT116, D...

Additional file 1: Figure S1. of Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration

Khayal Al-Khayal (3613457)
Ahmed Alafeefy (3613460)
Mansoor-Ali Vaali-Mohammed (2839421)
Amer Mahmood (284424)
Ahmed Zubaidi (3613463)
Omar Al-Obeed (487075)
Zahid Khan (341388)
Maha Abdulla (138948)
Rehan Ahmad (194760)

January 2017

SW620 cells were treated with 3c (5 μM) in the absence and presence of NAC (5 mM), Cell viability wa...

Additional file 3: Figure S1. of Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Zihang Xu (4028183)
Fei Zhang (85787)
Chao Bai (4428472)
Chao Yao (3745564)
Hairong Zhong (4428475)
Chunpu Zou (4428478)
Xiao Chen (260187)

September 2017

After pretreated with 20 μM z-VAD-fmk, a pan caspase inhibitor, for 1 h, Miapaca-S2 and PANC-1 cells...

Additional file 1: Figure S1. of Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling

Bruno Koehler (3536897)
Adam Jassowicz (3536894)
Anna-Lena Scherr (466377)
Stephan Lorenz (466378)
Praveen Radhakrishnan (3536891)
Nicole Kautz (466380)
Christin Elssner (466381)
Johanna Weiss (294205)
Dirk Jaeger (338273)
Martin Schneider (101577)
Henning Schulze-Bergkamen (466383)

November 2015

Chloroquine induces apoptosis in starving CRC cells via autophagy inhibition. A) HT29 and SW480 cell...

Additional file 6: Figure S4. of Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Zihang Xu (4028183)
Fei Zhang (85787)
Chao Bai (4428472)
Chao Yao (3745564)
Hairong Zhong (4428475)
Chunpu Zou (4428478)
Xiao Chen (260187)

September 2017

After pretreated with 5 mM NAC for 2 h, cells were treated with or without 20 μM Sophoridine for ind...

Promoting Effects of Sanguinarine on Apoptotic Gene Expression in Human Neuroblastoma Cells

AKTAŞ, SAFİYE
Ercetin, Pinar
ALTUN, ZEKİYE SULTAN
Cecen, Emre
Olgun, Nur

January 2014

Neuroblastoma is the most common extracranial solid tumor in children. Approximately half of the aff...

Additional file 2: Figure S1. of Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

Timothy Budden (441738)
Andre van der Westhuizen (4802022)
Nikola Bowden (3534809)

January 2018

Representative bright-field microscopy images of senescence associated β-galactosidase staining in a...

Additional file 2: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S2. Apoptosis was detected in HCT116 cells treated with sanguinarine. Cells were treated with...

Additional file 3: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S3. Apoptotic cells were significantly increased by sanguinarine treatment. Indicated CRC cel...

Additional file 5: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S5. Change of the mitochondrial membrane potential (MMP) in SW480 cells by sanguinarine. Cell...

Additional file 4: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S4. Z-VAD-fmk inhibited sanguinarine-induced apoptosis in CRC cells. After treatment with the...

Additional file 8: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Xianling Gong (5245292)
Zhihong Chen (38223)
Qinrui Han (5245295)
Chunhui Chen (119566)
Linlin Jing (5245289)
Yawei Liu (171534)
Liang Zhao (94728)
Xueqing Yao (5245286)
Xuegang Sun (338453)

May 2018

Figure S8. HCT116 WT and HCT116 Bax −/− cells were treated with sanguinarine for 12 h. RNA was extra...

Induction of apoptosis by sanguinarine in the bladder cancer cells.

Min Ho Han (586092)
Cheol Park (358509)
Cheng-Yun Jin (586093)
Gi-Young Kim (137710)
Young-Chae Chang (436164)
Sung-Kwon Moon (137717)
Wun-Jae Kim (81624)
Yung Hyun Choi (132605)

May 2013

<p>(A) The cells were incubated with 1.5 µM sanguinarine for 24 h and then stained with DAPI. The st...

Additional file 6: of The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivo

Pedro Cruz-Nova (5919875)
Michael Schnoor (419644)
José Correa-Basurto (472076)
Martiniano Bello (152281)
Paola Briseño-Diaz (5919893)
Arturo Rojo-Domínguez (5919902)
Carlos Ortiz-Mendoza (5919911)
Jorge Guerrero-Aguirre (5919917)
Francisco García-Vázquez (5919923)
Rosaura Hernández-Rivas (510505)
María del Rocío Thompson-Bonilla (3342392)
Miguel Vargas (85521)

November 2018

Figure S3. TUNEL staining of xenograft tumors. (A) Apoptotic cells appear green and nuclei were stai...

Additional file 1: Figure S1. of ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells

Reshma Thamkachy (3767449)
Rohith Kumar (465288)
K. Rajasekharan (3767446)
Suparna Sengupta (465292)

March 2016

Comparison of apoptosis in HCT116 and HCT116 p53 −/− cells treated with vinblastine : Cells were tre...

Additional file 4: Figure S3. of Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors

Alicja Pawlak (3453380)
Ewa Ziolo (3453386)
Anna Fiedorowicz (3453383)
Klaudyna Fidyt (3453374)
Leon Strzadala (3453377)
Wojciech Kalas (3453371)

November 2016

Combinatorial treatments increase CRC cell apoptosis. Annexin V-FITC/PI-double staining of HCT116, D...

Additional file 1: Figure S1. of Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration

Khayal Al-Khayal (3613457)
Ahmed Alafeefy (3613460)
Mansoor-Ali Vaali-Mohammed (2839421)
Amer Mahmood (284424)
Ahmed Zubaidi (3613463)
Omar Al-Obeed (487075)
Zahid Khan (341388)
Maha Abdulla (138948)
Rehan Ahmad (194760)

January 2017

SW620 cells were treated with 3c (5 μM) in the absence and presence of NAC (5 mM), Cell viability wa...

Additional file 3: Figure S1. of Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Zihang Xu (4028183)
Fei Zhang (85787)
Chao Bai (4428472)
Chao Yao (3745564)
Hairong Zhong (4428475)
Chunpu Zou (4428478)
Xiao Chen (260187)

September 2017

After pretreated with 20 μM z-VAD-fmk, a pan caspase inhibitor, for 1 h, Miapaca-S2 and PANC-1 cells...

Additional file 1: Figure S1. of Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling

Bruno Koehler (3536897)
Adam Jassowicz (3536894)
Anna-Lena Scherr (466377)
Stephan Lorenz (466378)
Praveen Radhakrishnan (3536891)
Nicole Kautz (466380)
Christin Elssner (466381)
Johanna Weiss (294205)
Dirk Jaeger (338273)
Martin Schneider (101577)
Henning Schulze-Bergkamen (466383)

November 2015

Chloroquine induces apoptosis in starving CRC cells via autophagy inhibition. A) HT29 and SW480 cell...

Additional file 6: Figure S4. of Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Zihang Xu (4028183)
Fei Zhang (85787)
Chao Bai (4428472)
Chao Yao (3745564)
Hairong Zhong (4428475)
Chunpu Zou (4428478)
Xiao Chen (260187)

September 2017

After pretreated with 5 mM NAC for 2 h, cells were treated with or without 20 μM Sophoridine for ind...

Promoting Effects of Sanguinarine on Apoptotic Gene Expression in Human Neuroblastoma Cells

AKTAŞ, SAFİYE
Ercetin, Pinar
ALTUN, ZEKİYE SULTAN
Cecen, Emre
Olgun, Nur

January 2014

Neuroblastoma is the most common extracranial solid tumor in children. Approximately half of the aff...

Additional file 2: Figure S1. of Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

Timothy Budden (441738)
Andre van der Westhuizen (4802022)
Nikola Bowden (3534809)

January 2018

Representative bright-field microscopy images of senescence associated β-galactosidase staining in a...

Additional file 1: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Abstract

Extracted data

Additional file 1: of Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Abstract

Extracted data

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