Histopathological alterations in brains, skeletal muscle, lungs of EV71-infected mice.

<p>Mice were sacrificed on 3, 5, 7 dpi. The removed organ or tissue were sliced and stained with H&E. Brain from EV71-infected mice exhibited perivascular cuffing (indicated by red solid arrows). Skeletal muscle from EV71-infected mice appeared necrotizing myositis with muscle fibers rupture (indicated by orange solid arrows) at 5 dpi and 7 dpi. Erythrocyte-filled fluid in the alveolar spaces was found in lungs (indicated by black solid arrows) from EV71-infected mice at 7 dpi. Bar = 100μm.