In situ EV71 distribution in hSCARB2-Tg mice.

<p>Seven-day-old hSACRB2-Tg and non-Tg mice infected with 3×10⁴ pfu of EV71 5746 s.c. were sacrificed on Day 7 post-infection. Uninfected hSCARB2-Tg mice were used as the negative control. Waxed sections of the brainstem, spinal cord, intestine, lung, biceps femoris muscle, and lower back skin were prepared and IHC stained with (<b>A</b>) Mab979 antibody or isotype mouse IgG and (<b>B</b>) the anti-CD3 antibody. All pictures were taken at 200X magnification. Viral particles or T lymphocytes in the sections are indicated with arrows. The melanin pigments (MP) pale-stained by Mab979 antibody in the section of skin tissue was observed.