Process diagram.

<p>a) Activation/deactivation of PKMζ mRNA (blue). Translational repression of mRNA is lifted by catalytic activity of PKMζ, possibly by phosphorylation of mRNA-binding proteins. A phosphatase (pink) dephosphorylates the same proteins, returning mRNA to its repressed state. b) Synthesis and degradation/dissipation of PKMζ (cyan). Synthesis consists in local translation of PKMζ mRNA. Degradation and/or dissipation away from the synaptic compartment is inhibited by inserted GluA2-containing AMPARs. c) Trafficking of GluA2-containing AMPARs (green) into and out of the PSD. Insertion is facilitated by PKMζ, and removal (endocytosis) by the BRAG2 protein. d) Inhibition/disinhibition of BRAG2-GluA2 interaction. Inhibition is modeled as phosphorylation of BRAG2 (orange) catalyzed by PKMζ, and disinhibition as dephosphorylation catalyzed by a phosphatase. E1 and E2 (dark green) are enzymes activated by NMDAR stimulation at L-LTP induction and memory reactivation, respectively. The effects of PSI, ZIP and GluA2_3Y (red) are modeled by disabling the indicated catalytic reactions. Solid arrows represent chemical reactions and receptor trafficking. Dashed lines with filled circles represent catalytic activity. Dashed lines with crossbars represent inhibition.