PSI infusion during the maintenance phase does not disrupt established L-LTP.

<p>L-LTP is induced by NMDAR stimulation at “Stim”. Once L-LTP is established (100 minutes after induction), protein synthesis inhibition is applied for 100 minutes. The interruption of kinase synthesis causes a decline in the levels of PKMζ and inserted GluA2-containing AMPARs, but the synapse recovers when the PSI is removed. Solid lines represent mean molecule counts for 100 simulations. Lightly colored bands indicate standard deviation. RA: active PKMζ mRNA, P: PKMζ, A_I: inserted GluA2-containing AMPARs, E1_A: activated E1 enzyme.