<p>NMDAR stimulation is simulated by instantaneous activation of 100 E1 molecules at “Stim”. E1 lifts the translational inhibition of PKMζ mRNA, synthesis of PKMζ starts, PKMζ drives up the number of inserted GluA2-containing AMPARs, and the synapse switches to its potentiated steady state. R<sub>A</sub>: active PKMζ mRNA, P: PKMζ, A<sub>I</sub>: inserted GluA2-containing AMPARs, E1<sub>A</sub>: activated E1 enzyme.</p
<p>(<i>A)</i> Schematic representation of the experimental design. (<i>B</i>) NMDAR-dependent LTP in...
Long-term potentiation (LTP) is a key candidate for cellular and molecular mechanisms underlying mem...
<p>Induction of chemically induced late phase LTP was simulated with a 5 Hz frequency of glutamate r...
<p>The same simulation as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.p...
<p>L-LTP is induced by NMDAR stimulation at “Stim”. Once L-LTP is established (100 minutes after ind...
<p>NMDAR stimulation is simulated by a pulse of active E1 enzyme at “Stim”, and reactivation by a pu...
<p><i>Synaptic NMDAR stimulation</i>, High KCl concentration depolarizes synaptosomes releasing endo...
<p><i> Left:</i> Normalized slopes of evoked fEPSPs recorded as those in <a href="http://www.plosone...
<p>In this simulation the endocytotic effect of the reactivation-triggered pulse of active E2 enzyme...
<p><b>A</b>, Schematic representation of the slice preparation showing positions of stimulation (S<s...
<p>Electrical stimuli (tetanus or theta-burst) elevate synaptic and nuclear Ca<sup>2+</sup>. Steep s...
grantor: University of TorontoLong-term potentiation (LTP) is an activity-dependent streng...
<p>(<i>A</i>) The induction of LTP in the hippocampal DG requires activation of NMDARs. A stable bas...
AbstractLong-term potentiation (LTP) and long-term depression (LTD) are the major forms of functiona...
<p>a) Activation/deactivation of PKMζ mRNA (blue). Translational repression of mRNA is lifted by cat...
<p>(<i>A)</i> Schematic representation of the experimental design. (<i>B</i>) NMDAR-dependent LTP in...
Long-term potentiation (LTP) is a key candidate for cellular and molecular mechanisms underlying mem...
<p>Induction of chemically induced late phase LTP was simulated with a 5 Hz frequency of glutamate r...
<p>The same simulation as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.p...
<p>L-LTP is induced by NMDAR stimulation at “Stim”. Once L-LTP is established (100 minutes after ind...
<p>NMDAR stimulation is simulated by a pulse of active E1 enzyme at “Stim”, and reactivation by a pu...
<p><i>Synaptic NMDAR stimulation</i>, High KCl concentration depolarizes synaptosomes releasing endo...
<p><i> Left:</i> Normalized slopes of evoked fEPSPs recorded as those in <a href="http://www.plosone...
<p>In this simulation the endocytotic effect of the reactivation-triggered pulse of active E2 enzyme...
<p><b>A</b>, Schematic representation of the slice preparation showing positions of stimulation (S<s...
<p>Electrical stimuli (tetanus or theta-burst) elevate synaptic and nuclear Ca<sup>2+</sup>. Steep s...
grantor: University of TorontoLong-term potentiation (LTP) is an activity-dependent streng...
<p>(<i>A</i>) The induction of LTP in the hippocampal DG requires activation of NMDARs. A stable bas...
AbstractLong-term potentiation (LTP) and long-term depression (LTD) are the major forms of functiona...
<p>a) Activation/deactivation of PKMζ mRNA (blue). Translational repression of mRNA is lifted by cat...
<p>(<i>A)</i> Schematic representation of the experimental design. (<i>B</i>) NMDAR-dependent LTP in...
Long-term potentiation (LTP) is a key candidate for cellular and molecular mechanisms underlying mem...
<p>Induction of chemically induced late phase LTP was simulated with a 5 Hz frequency of glutamate r...
DOI
Add to ORKG