Heatmap of the methylation markers investigated and their differential methylation with respect to the investigated tissue types.

<p>On the bottom x-axis each investigated patient with its entity identifier is depicted. The upper x-axis shows the binary clusters of the entity groups with respect to the methylation markers, which are shown on the y-axis. Each tumor entity is represented by one of the red colors, whereas green represents benign tissue. The main clusters represent benign (predominantly green) versus tumor (predominantly red) samples. Benign tissue shows differential methylation compared to tumors with respect to <i>EFEMP1</i>, <i>L1RE1</i>, <i>RARB</i>, and <i>RASSF1</i>.