Detailed description of each case for the 3-state model.

<p>The first seven cases correspond to the chain that has the third state observable (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006206#pcbi.1006206.g003" target="_blank">Fig 3</a>). The last five cases have the middle state as the observable state. Transition rates <i>α</i>_<i>k</i> for <i>k</i> = 1, 2, 3, 4 are given by columns 3-6. The final column shows the characterization of each case into one of six different types determined by their edge importance graph as a function of parameter <i>α</i> (see right most column in Figs <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006206#pcbi.1006206.g005" target="_blank">5</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006206#pcbi.1006206.g006" target="_blank">6</a>).