MOESM9 of CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites

Additional file 9: Fig. S7 . CRX is required to activate Dependent Group C enhancer elements and remodel chromatin. Plots display mean (black line) and SEM (gray bars) of DNase I data presented in Fig. 5a for CRX Dependent (a) and Independent (b) sites. (Two-way ANOVA with Tukey multiple comparison testing; **** p<0.0001) (c) Scatterplot displays changes in H3K27Ac deposition at all peaks (light gray). Black and red denote the subset of H3K27Ac peaks that contain CRX Independent and Dependent Group C sites. (d) Quantification of the fold-change of H3K27Ac deposition in WT vs Crx-/-. (Wilcoxon Rank Sum Test; **** p < 2.2 × 10−16