Objectives The aim of the paper is to apply Open Building approach at the room scale, developing a meta-design solution able to address flexibility through prefabrication in future healthcare environments. Background In recent years, several studies have revealed the increasing rate of hospital obsolescence. This fact reflects the fast pace at which contemporary society, medical and technological knowledge evolve. Several scholars underline that in the next 20 years 80% of medicine will change. Therefore, architectures for health must be resilient and able to adapt to unpredictable changes within different country’s healthcare systems and organizational models. Method Within Alta Scuola Politecnica multidisciplinary projects, Open Bui...