In recent years, many studies have revealed the increasing rate of hospital obsolescence: this fact is a reflection of the fast pace at which contemporary society and medical knowledge evolve. The main challenge is to realize flexible healthcare facilities able to update their services in time. Objective. Starting from the Open Building design approach, the current development of prefabricated technologies in construction industry and the application of Plug-In users’ rooms in hotel facilities, a multidisciplinary research group (coordinated by the authors) develops a new approach in flexibility in hospital wards with the Open Room, predisposed to respond to several functions. Methodology. The design approach is structured into three area...