Comparative pharmacokinetics of formulations after 16 days of administration.

<p>Male Sprague-Dawley rats (N = 4/group) received once daily for 16 days administration of 90 mg/kg active via BBR oral gavage (BBR PO; ▼), 5% (w/w) BBR transdermal formulation (BBR TD; -■-), 5% (w/w) DHB transdermal formulation (DHB TD; -●-), or vehicle control (Vehicle TD; ▲) and serum collected over the course of nine hours. Error bars represent standard error of the mean.