A demographic study on relation between uric acid and diabetes parameters in the Chhattisgarh State of India

Objective: Epidemiological evidence suggest that conflicting data exist for the relation between serum uric acid (SUA) and various diabetes-associated parameters. Therefore, measurement of SUA levels could play a valuable role as predictor marker in early type 2 diabetics as well as a potent antioxidant therapeutic. This work is a small demographic study in the patients of Chhattisgarh to find a relation between the SUA level and diabetes parameters in diabetics and controls. Materials and Methods: This was a small sample set case–control study. Patients were divided into two groups, namely, control (n = 25) and type 2 diabetics (n = 30). Biochemical estimation of parameters was performed using commercially available enzymatic kits. Results: Plasma glucose, serum triglyceride, glycated haemoglobin and creatinine were higher in diabetic patients than in controls. SUA showed a significant lower level in test patients (2.97 ± 0.22) as compared to control (4.35 ± 0.64). A negative correlation of r = −0.8159 was obtained between SUA and plasma glucose levels. Conclusions: Results suggest that variation in uric acid (UA) levels from normal to pre-diabetes and diabetes condition could be an important biomarker. Further validations may pave the way for UA measurement as a diagnostic and prognostic marker in type 2 diabetes mellitus