Comparisons between human and rodent genomic sequences in the vicinity of the DBP locus

<p><b>Copyright information:</b></p><p>Taken from "The human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatin"</p><p>Nucleic Acids Research 2006;34(8):2154-2165.</p><p>Published online 28 Apr 2006</p><p>PMCID:PMC1450336.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> A map of the gene is displayed in the center of the figure showing the exon-intron arrangement and location of the HS in liver (downward arrows) and brain (upward arrows). An expanded view of the sequence comparisons (human compared to rodent) in the 5′-flanking region (upper panel) and intron 1 (lower panel) are shown. The numbering on the -axis refers to the position in the human sequence. The level of similarity in sequence is displayed on the -axis as a percentage (mVISTA program; window size 50 bp, homology threshold 70%). The 75% level of sequence similarity is marked by a horizontal line and regions of the sequence representing repeated elements are indicated by the shaded rectangles, LINE elements (stippled) and SINE (solid). The positions of liver-specific HSI, HSIII, HSIV and HSV sequence comparisons are each indicated by the downward arrows. Note the peaks of sequence identity at each of the indicated DNase I HS