Comparison of mammalian <i>IGF1/Igf1</i> genes and loci.

<p>Schematics of rat <i>Igf1</i>, and selected other <i>IGF1</i>/<i>Igf1</i> genes and loci are shown. Exons are depicted as boxes, and introns and flanking DNA as horizontal lines. The enlargement above the main map depicts the two rat <i>Igf1</i> promoters, P1 and P2, and exons 1–3. Red circles represent locations of sites shown to bind Stat5b in a GH-inducible way in the rat <i>Igf1</i> locus, and their homologues in other species. A filled circle indicates the presence of intact Stat5b binding elements, an open circle depicts that one Stat5b site is absent, and an X within a circle represents the absence of all Stat5b binding sequences (see Tables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0189642#pone.0189642.t005" target="_blank">5</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0189642#pone.0189642.t006" target="_blank">6</a>). The percentage of nucleotide identity with different parts of rat <i>Igf1</i> is indicated within each gene and locus (black for exons, red for putative Stat5b binding elements). Other abbreviations are as follows: R2-3, R8-9, R13, R34-35, R53-54, R57-59, R60-61-78—nomenclature for rat Stat5b sites (see (37)). A similar nomenclature has been adopted for other species.