A comparative encyclopedia of DNA elements in the mouse genome
- Yue, F.
- Cheng, Y.
- Breschi, A.
- Vierstra, J.
- Wu, W.
- Ryba, T.
- Sandstrom, R.
- Ma, Z.
- Davis, C.
- Pope, B. D.
- Shen, Y.
- Pervouchine, D. D.
- Djebali, S.
- Thurman, R. E.
- Kaul, R.
- Rynes, E.
- Kirilusha, A.
- Marinov, G. K.
- Williams, B. A.
- Trout, D.
- Amrhein, H.
- Fisher-Aylor, K.
- Antoshechkin, I.
- DeSalvo, G.
- See, L. H.
- Fastuca, M.
- Drenkow, J.
- Zaleski, C.
- Dobin, A.
- Prieto, P.
- Lagarde, J.
- Bussotti, G.
- Tanzer, A.
- Denas, O.
- Li, K.
- Bender, M. A.
- Zhang, M.
- Byron, R.
- Groudine, M. T.
- McCleary, D.
- Pham, L.
- Ye, Z.
- Kuan, S.
- Edsall, L.
- Wu, Y. C.
- Rasmussen, M. D.
- Bansal, M. S.
- Kellis, M.
- Keller, C. A.
- Morrissey, C. S.
- Mishra, T.
- Jain, D.
- Dogan, N.
- Harris, R. S.
- Cayting, P.
- Kawli, T.
- Boyle, A. P.
- Euskirchen, G.
- Kundaje, A.
- Lin, S.
- Lin, Y.
- Jansen, C.
- Malladi, V. S.
- Cline, M. S.
- Erickson, D. T.
- Kirkup, V. M.
- Learned, K.
- Sloan, C. A.
- Rosenbloom, K. R.
- Lacerda de Sousa, B.
- Beal, K.
- Pignatelli, M.
- Flicek, P.
- Lian, J.
- Kahveci, T.
- Lee, D.
- Kent, W. J.
- Ramalho Santos, M.
- Herrero, J.
- Notredame, C.
- Johnson, A.
- Vong, S.
- Lee, K.
- Bates, D.
- Neri, F.
- Diegel, M.
- Canfield, T.
- Sabo, P. J.
- Wilken, M. S.
- Reh, T. A.
- Giste, E.
- Shafer, A.
- Kutyavin, T.
- Haugen, E.
- Dunn, D.
- Reynolds, A. P.
- Neph, S.
- Humbert, R.
- Hansen, R. S.
- De Bruijn, M.
DOIAbstract
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcrip...
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