Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism-1

Emonstrate that intracardiac intracellular adhesion molecule-1 (ICAM-1) (red) is dramatically increased in the former. Fibrinogen (green) was greatly increased outside the endothelium (von Willebrand factor labeled red) in the LPS group compared with rats treated with saline. Group mean data of the fold increases in myocardial ICAM-1 expression and perivascular fibrinogen deposition in LPS-treated versus saline-treated animals. *< 0.05 versus saline.<p><b>Copyright information:</b></p><p>Taken from "Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism"</p><p>http://ccforum.com/content/12/1/R2</p><p>Critical Care 2008;12(1):R2-R2.</p><p>Published online 3 Jan 2008</p><p>PMCID:PMC2374637.</p><p>