) and E13.5 (C-H). mutant embryos (B, D, F, H) exhibited blood pooling (asterisks) and loss of visible vascular structures (arrowheads mark similar vessels; compare A & B, C & D, E & F, and G & H).<p><b>Copyright information:</b></p><p>Taken from "Endothelial-specific ablation of Serum Response Factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality"</p><p>http://www.biomedcentral.com/1471-213X/8/65</p><p>BMC Developmental Biology 2008;8():65-65.</p><p>Published online 20 Jun 2008</p><p>PMCID:PMC2442838.</p><p></p
Serum response factor (SRF) is a transcription factor that controls the expression of cytoskeletal p...
SummarySerum response factor (SRF) is a transcription factor that controls the expression of cytoske...
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...
Sac tissues from mutant embryos showed disorganized vascular networks at E12.5 (B) that become more ...
Os (B, D, F, H) exhibited internal hemorrhaging compared to wild-type littermates (A, C, E, G). This...
Nd E13.5 (G, H). Embryos with genotype exhibited severely disrupted vascular networks at E12.5 (F) a...
of wild-type (A) and (B) whole yolk sac at E13.5; arrowheads (B) mark apparent blood vessel remnants...
Ker PECAM-1 to detect vascular structures. Vessels on ventral (A, B) and dorsal (C, D) heart surface...
Green). Immunofluorescent analysis revealed a decrease in detectable E-cadherin protein in mutant sa...
Trastructural detail. Desmosomal-type junctional complexes are observed in wild-type tissue (B arrow...
Labelled with the VEC marker PECAM-1 (red) and SRF (green). (A) PECAM-1-stained cells surround vesse...
<p>(<b>A</b>) 34 hpf rescued embryo with heart beat and blood flow, resembling a ctrl MO embryo at t...
<p>(A), the wild type (+/+) and mutant (−/−) embryos at E10.5 were stained using PECAM-1. (B), HE st...
Tissue factor, a member of the cytokine-receptor superfamily and high-affinity receptor and cofactor...
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...
Serum response factor (SRF) is a transcription factor that controls the expression of cytoskeletal p...
SummarySerum response factor (SRF) is a transcription factor that controls the expression of cytoske...
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...
Sac tissues from mutant embryos showed disorganized vascular networks at E12.5 (B) that become more ...
Os (B, D, F, H) exhibited internal hemorrhaging compared to wild-type littermates (A, C, E, G). This...
Nd E13.5 (G, H). Embryos with genotype exhibited severely disrupted vascular networks at E12.5 (F) a...
of wild-type (A) and (B) whole yolk sac at E13.5; arrowheads (B) mark apparent blood vessel remnants...
Ker PECAM-1 to detect vascular structures. Vessels on ventral (A, B) and dorsal (C, D) heart surface...
Green). Immunofluorescent analysis revealed a decrease in detectable E-cadherin protein in mutant sa...
Trastructural detail. Desmosomal-type junctional complexes are observed in wild-type tissue (B arrow...
Labelled with the VEC marker PECAM-1 (red) and SRF (green). (A) PECAM-1-stained cells surround vesse...
<p>(<b>A</b>) 34 hpf rescued embryo with heart beat and blood flow, resembling a ctrl MO embryo at t...
<p>(A), the wild type (+/+) and mutant (−/−) embryos at E10.5 were stained using PECAM-1. (B), HE st...
Tissue factor, a member of the cytokine-receptor superfamily and high-affinity receptor and cofactor...
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...
Serum response factor (SRF) is a transcription factor that controls the expression of cytoskeletal p...
SummarySerum response factor (SRF) is a transcription factor that controls the expression of cytoske...
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...