Sac tissues from mutant embryos showed disorganized vascular networks at E12.5 (B) that become more pronounced at E13.5 (D, F arrowheads). Blood pools (B, asterisks) were also observed in mutant yolk sac tissues.<p><b>Copyright information:</b></p><p>Taken from "Endothelial-specific ablation of Serum Response Factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality"</p><p>http://www.biomedcentral.com/1471-213X/8/65</p><p>BMC Developmental Biology 2008;8():65-65.</p><p>Published online 20 Jun 2008</p><p>PMCID:PMC2442838.</p><p></p
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...
<p>(<b>A</b>) 34 hpf rescued embryo with heart beat and blood flow, resembling a ctrl MO embryo at t...
SummarySerum response factor (SRF) is a transcription factor that controls the expression of cytoske...
) and E13.5 (C-H). mutant embryos (B, D, F, H) exhibited blood pooling (asterisks) and loss of visib...
Nd E13.5 (G, H). Embryos with genotype exhibited severely disrupted vascular networks at E12.5 (F) a...
of wild-type (A) and (B) whole yolk sac at E13.5; arrowheads (B) mark apparent blood vessel remnants...
Os (B, D, F, H) exhibited internal hemorrhaging compared to wild-type littermates (A, C, E, G). This...
Trastructural detail. Desmosomal-type junctional complexes are observed in wild-type tissue (B arrow...
Ker PECAM-1 to detect vascular structures. Vessels on ventral (A, B) and dorsal (C, D) heart surface...
Green). Immunofluorescent analysis revealed a decrease in detectable E-cadherin protein in mutant sa...
Labelled with the VEC marker PECAM-1 (red) and SRF (green). (A) PECAM-1-stained cells surround vesse...
Tissue factor, a member of the cytokine-receptor superfamily and high-affinity receptor and cofactor...
<p>(A), the wild type (+/+) and mutant (−/−) embryos at E10.5 were stained using PECAM-1. (B), HE st...
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...
<p>A–B, D–E) Whole mount immunofluorescence of 9.5 <i>dpc</i> WT (A–B) or mutant (D–E) yolk sacs (YS...
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...
<p>(<b>A</b>) 34 hpf rescued embryo with heart beat and blood flow, resembling a ctrl MO embryo at t...
SummarySerum response factor (SRF) is a transcription factor that controls the expression of cytoske...
) and E13.5 (C-H). mutant embryos (B, D, F, H) exhibited blood pooling (asterisks) and loss of visib...
Nd E13.5 (G, H). Embryos with genotype exhibited severely disrupted vascular networks at E12.5 (F) a...
of wild-type (A) and (B) whole yolk sac at E13.5; arrowheads (B) mark apparent blood vessel remnants...
Os (B, D, F, H) exhibited internal hemorrhaging compared to wild-type littermates (A, C, E, G). This...
Trastructural detail. Desmosomal-type junctional complexes are observed in wild-type tissue (B arrow...
Ker PECAM-1 to detect vascular structures. Vessels on ventral (A, B) and dorsal (C, D) heart surface...
Green). Immunofluorescent analysis revealed a decrease in detectable E-cadherin protein in mutant sa...
Labelled with the VEC marker PECAM-1 (red) and SRF (green). (A) PECAM-1-stained cells surround vesse...
Tissue factor, a member of the cytokine-receptor superfamily and high-affinity receptor and cofactor...
<p>(A), the wild type (+/+) and mutant (−/−) embryos at E10.5 were stained using PECAM-1. (B), HE st...
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...
<p>A–B, D–E) Whole mount immunofluorescence of 9.5 <i>dpc</i> WT (A–B) or mutant (D–E) yolk sacs (YS...
Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encod...
<p>(<b>A</b>) 34 hpf rescued embryo with heart beat and blood flow, resembling a ctrl MO embryo at t...
SummarySerum response factor (SRF) is a transcription factor that controls the expression of cytoske...