Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response-0

Nt. (B) Mice were immunized five times i.p. with the same envelope antigens and Ribi adjuvant. Splenocytes were collected two weeks after the final boost and tested for envelope-specific proliferation by H-thymidine incorporation. Proliferation in the presence of antigen (3 μg/ml) or medium alone was measured after a 5-day culture. The stimulation indices of individual mice and the mean values for each group (horizontal bars) are shown. Statistical analyses were done using one-way ANOVA with Bonferroni's multiple comparison test.<p><b>Copyright information:</b></p><p>Taken from "Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response"</p><p>http://www.infectagentscancer.com/content/3/1/11</p><p>Infectious Agents and Cancer 2008;3():11-11.</p><p>Published online 18 Jul 2008</p><p>PMCID:PMC2503958.</p><p>