Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response-1

Bs mAb 654 or anti-C5 mAb 450 (10 μg/ml each). B) Proliferation of clone T1 was tested in response to different gp120/mAb complexes. For comparison, the response to gp120 alone is normalized to 100%. Gp120 was tested at 3 μg/ml and combined with 10 μg/ml of each mAb. Irradiated splenocytes were used as antigen-presenting cells. Average values and standard deviation from two repeated experiments are shown.<p><b>Copyright information:</b></p><p>Taken from "Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response"</p><p>http://www.infectagentscancer.com/content/3/1/11</p><p>Infectious Agents and Cancer 2008;3():11-11.</p><p>Published online 18 Jul 2008</p><p>PMCID:PMC2503958.</p><p>