Time course of nicotine and beta-amyloid evoked GABA (A), glutamate (B) and aspartate (C) release <i>in vitro</i>.

<p>Synaptosomes were depolarized with nicotine (Nic) or beta-amyloid (Aβ)1–40 for 90 s at <i>t</i> = 38 min of superfusion (black bar). Values represent mean ± SEM of at least eight replicate superfusion chambers per condition (basal or evoked release). *p<0.05, **p<0.01 vs. GABA basal release; ^#p<0.05; ^##p<0.01 vs. glutamate (Glu) basal release; ^°°p<0.01 vs. aspartate (Asp) basal release. Two way ANOVA followed by Bonferroni <i>post hoc</i> test.