<i>In vivo</i> effect of different concentrations of beta-amyloid on the nicotine-induced overflow of hippocampal neurotransmitters.

<p>Effect of beta-amyloid (Aβ)1–40 (100 nM–10 µM) on 50 mM nicotine (Nic)-induced overflow of GABA (<b>A</b>), glutamate (Glu, <b>B</b>) and aspartate (Asp, <b>C</b>). *p<0.05, **p<0.01, ***p<0.001 vs. Nic (One-way ANOVA followed by Dunnett's Multiple Comparison Test). Data are expressed as mean ± SEM of 4–15 individual rats for each experimental group. Insets show the time course of 50 mM Nic-induced release of GABA (<b>A inset</b>), Glu (<b>B inset</b>) and Asp (<b>C inset</b>). *p<0.05, **p<0.01 vs. basal release (One-way ANOVA followed by Bonferroni <i>post hoc</i> test). Data are expressed as mean ± SEM of 13–15 individual rats.