Losartan reduces TGFβ-induced gene expression in tumors from <i>SPARC−/−</i> mice.
- Shanna A. Arnold (183991)
- Lee B. Rivera (183996)
- Juliet G. Carbon (183999)
- Jason E. Toombs (184000)
- Chi-Lun Chang (184003)
- Amy D. Bradshaw (184007)
- Rolf A. Brekken (184013)
Publication date
February 2012
DOIAbstract
<p>(A) The mRNA expression of TGFβ1, TGFβ3 and TSP-1 in tumors from <i>SPARC+/+</i> and <i>SPARC−/−</i> mice treated with losartan was assessed with taqman-based qPCR. n = 3/group and p-values were calculated with the Student's t-test. (B) Clustergram results from the RT<sup>2</sup> Profiler™ PCR Array (PAMM-035; SABiosciences). Green indicates negative fold-regulation, whereas red indicates positive fold-regulation relative to six internal control genes.</p
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