Lipid droplet size is reduced in Rab32/ltd and Rab32 GEF/ca mutants.

A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans

Shiwei Li
Shibin Xu
Yanli Ma
Shuang Wu
Yu Feng
Qingpo Cui
Lifeng Chen
Shuang Zhou
Yuanyuan Kong
Xiaoyu Zhang
Jialei Yu
Mengdi Wu
Shaobing O. Zhang

August 2016

To identify genes that regulate the dynamics of lipid droplet (LD) size, we have used the geneticall...

Lipid levels and distribution are altered in pry-1(mu38) mutants.

Ayush Ranawade (5942681)
Avijit Mallick (5942684)
Bhagwati P. Gupta (213804)

November 2018

Arrowheads indicate intestine and dotted areas gonad. (A) Representative DIC images of N2 and pry-1(...

Among three TBP family members in Drosophila, only TRF2 specifically regulates LD size.

Wei Fan (109074)
Sin Man Lam (200854)
Jingxue Xin (3820891)
Xiao Yang (19898)
Zhonghua Liu (148625)
Yuan Liu (88411)
Yong Wang (12837)
Guanghou Shui (136742)
Xun Huang (163341)

March 2017

(A) Knockdown of trf2 in larval fat body leads to increased LD size whereas knockdown of <...

Genetic screen for Rabs that affect the size of lipid droplets.

Chao Wang (146527)
Zhonghua Liu (148625)
Xun Huang (163341)

February 2012

(A) Nile red staining of lipid droplets in wandering stage third instar larval fat body cells. Do...

ltd, ca and rb affect lipid storage.

Chao Wang (146527)
Zhonghua Liu (148625)
Xun Huang (163341)

February 2012

(A) Lipid droplets in different eye pigment granule biogenesis mutants. Nile red staining of lipi...

ltd and ca genetically interact with the two lipolysis-related genes bmm and plin2.

Chao Wang (146527)
Zhonghua Liu (148625)
Xun Huang (163341)

February 2012

(A) Image and fluorescence intensity quantification of lipogenic reporter Gal4-SREBP>UAS-GFP in <...

Number and size of lipid droplets are decreased in the Δgph1 deletion mutant.

Martina Gsell (469689)
Ariane Fankl (779343)
Lisa Klug (558231)
Gerald Mascher (469690)
Claudia Schmidt (190561)
Claudia Hrastnik (469692)
Günther Zellnig (779345)
Günther Daum (469693)

September 2015

(A) Transmission electron microscopy images of wild type BY4741 and Δgph1. (B) Nile Red st...

CGI-58 is essential for lipid droplet size regulation.

Meng Xie (501184)
Richard Roy (652797)

June 2015

(A) Elimination of cgi-58 in daf-2 and daf-2; aak(0) animals led to a...

Autophagy is impaired in ca mutants and defective autophagy leads to small lipid droplets.

Chao Wang (146527)
Zhonghua Liu (148625)
Xun Huang (163341)

February 2012

(A) Autophagy marker EGFP-huLC3-positive puncta are greatly reduced in ltd1 and...

Changes in lipid and amino acid profiles in mlx1 mutants.

Essi Havula (399263)
Mari Teesalu (399264)
Tuulia Hyötyläinen (139327)
Heini Seppälä (399265)
Kiran Hasygar (399266)
Petri Auvinen (15704)
Matej Orešič (43155)
Thomas Sandmann (36795)
Ville Hietakangas (109633)

April 2013

(A) Phospholipid levels in control and mlx1 mutant larvae. PE: phosphatidyletha...

acs-20 mutants are strongly stained with lipophilic dyes, but their lipid contents are not altered.

Eriko Kage-Nakadai (143531)
Hiroyuki Kobuna (244516)
Masako Kimura (367716)
Keiko Gengyo-Ando (113317)
Takao Inoue (244518)
Hiroyuki Arai (37989)
Shohei Mitani (143535)

February 2013

(A) Wild-type (left panels) and acs-20 (tm3232) mutant (right panels) animals are stained ...

cycGHR7 mutant animals show defects in fat metabolism.

Patrick Fischer (783820)
Martina K. La Rosa (783821)
Adriana Schulz (489180)
Anette Preiss (33103)
Anja C. Nagel (86923)

August 2015

(A) Wild type (Wt) and cycGHR7 mutants similarly ingest food as visualiz...

Increased lipid droplet aggregates were observed in CGI-58-deficient Dauers.

Meng Xie (501184)
Richard Roy (652797)

June 2015

(A)-(F)cgi-58, but not atgl-1, limits the formation of lipid droplet aggrega...

Increased lipid concentrations are common in STHdhQ111/Q111 cell pellets.

Jeffrey B. Carroll (628020)
Amy Deik (785833)
Elisa Fossale (785834)
Rory M. Weston (785835)
Jolene R. Guide (136560)
Jamshid Arjomand (519926)
Seung Kwak (720428)
Clary B. Clish (242594)
Marcy E. MacDonald (223720)

August 2015

A) Strip-plots summarize the logarithm of the concentration ratios of metabolites altered in muta...

ATGL-1 Compromise Causes Enlarged Lipid Droplets in C. elegans Dauer Larvae.

Meng Xie (501184)
Richard Roy (652797)

June 2015

(A)-(F) Disruption of ATGL-1, but not HSL function in both control daf-2(A),...

A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans

Shiwei Li
Shibin Xu
Yanli Ma
Shuang Wu
Yu Feng
Qingpo Cui
Lifeng Chen
Shuang Zhou
Yuanyuan Kong
Xiaoyu Zhang
Jialei Yu
Mengdi Wu
Shaobing O. Zhang

August 2016

To identify genes that regulate the dynamics of lipid droplet (LD) size, we have used the geneticall...

Lipid levels and distribution are altered in pry-1(mu38) mutants.

Ayush Ranawade (5942681)
Avijit Mallick (5942684)
Bhagwati P. Gupta (213804)

November 2018

Arrowheads indicate intestine and dotted areas gonad. (A) Representative DIC images of N2 and pry-1(...

Among three TBP family members in Drosophila, only TRF2 specifically regulates LD size.

Wei Fan (109074)
Sin Man Lam (200854)
Jingxue Xin (3820891)
Xiao Yang (19898)
Zhonghua Liu (148625)
Yuan Liu (88411)
Yong Wang (12837)
Guanghou Shui (136742)
Xun Huang (163341)

March 2017

(A) Knockdown of trf2 in larval fat body leads to increased LD size whereas knockdown of <...

Genetic screen for Rabs that affect the size of lipid droplets.

Chao Wang (146527)
Zhonghua Liu (148625)
Xun Huang (163341)

February 2012

(A) Nile red staining of lipid droplets in wandering stage third instar larval fat body cells. Do...

ltd, ca and rb affect lipid storage.

Chao Wang (146527)
Zhonghua Liu (148625)
Xun Huang (163341)

February 2012

(A) Lipid droplets in different eye pigment granule biogenesis mutants. Nile red staining of lipi...

ltd and ca genetically interact with the two lipolysis-related genes bmm and plin2.

Chao Wang (146527)
Zhonghua Liu (148625)
Xun Huang (163341)

February 2012

(A) Image and fluorescence intensity quantification of lipogenic reporter Gal4-SREBP>UAS-GFP in <...

Number and size of lipid droplets are decreased in the Δgph1 deletion mutant.

Martina Gsell (469689)
Ariane Fankl (779343)
Lisa Klug (558231)
Gerald Mascher (469690)
Claudia Schmidt (190561)
Claudia Hrastnik (469692)
Günther Zellnig (779345)
Günther Daum (469693)

September 2015

(A) Transmission electron microscopy images of wild type BY4741 and Δgph1. (B) Nile Red st...

CGI-58 is essential for lipid droplet size regulation.

Meng Xie (501184)
Richard Roy (652797)

June 2015

(A) Elimination of cgi-58 in daf-2 and daf-2; aak(0) animals led to a...

Autophagy is impaired in ca mutants and defective autophagy leads to small lipid droplets.

Chao Wang (146527)
Zhonghua Liu (148625)
Xun Huang (163341)

February 2012

(A) Autophagy marker EGFP-huLC3-positive puncta are greatly reduced in ltd1 and...

Changes in lipid and amino acid profiles in mlx1 mutants.

Essi Havula (399263)
Mari Teesalu (399264)
Tuulia Hyötyläinen (139327)
Heini Seppälä (399265)
Kiran Hasygar (399266)
Petri Auvinen (15704)
Matej Orešič (43155)
Thomas Sandmann (36795)
Ville Hietakangas (109633)

April 2013

(A) Phospholipid levels in control and mlx1 mutant larvae. PE: phosphatidyletha...

acs-20 mutants are strongly stained with lipophilic dyes, but their lipid contents are not altered.

Eriko Kage-Nakadai (143531)
Hiroyuki Kobuna (244516)
Masako Kimura (367716)
Keiko Gengyo-Ando (113317)
Takao Inoue (244518)
Hiroyuki Arai (37989)
Shohei Mitani (143535)

February 2013

(A) Wild-type (left panels) and acs-20 (tm3232) mutant (right panels) animals are stained ...

cycGHR7 mutant animals show defects in fat metabolism.

Patrick Fischer (783820)
Martina K. La Rosa (783821)
Adriana Schulz (489180)
Anette Preiss (33103)
Anja C. Nagel (86923)

August 2015

(A) Wild type (Wt) and cycGHR7 mutants similarly ingest food as visualiz...

Increased lipid droplet aggregates were observed in CGI-58-deficient Dauers.

Meng Xie (501184)
Richard Roy (652797)

June 2015

(A)-(F)cgi-58, but not atgl-1, limits the formation of lipid droplet aggrega...

Increased lipid concentrations are common in STHdhQ111/Q111 cell pellets.

Jeffrey B. Carroll (628020)
Amy Deik (785833)
Elisa Fossale (785834)
Rory M. Weston (785835)
Jolene R. Guide (136560)
Jamshid Arjomand (519926)
Seung Kwak (720428)
Clary B. Clish (242594)
Marcy E. MacDonald (223720)

August 2015

A) Strip-plots summarize the logarithm of the concentration ratios of metabolites altered in muta...

ATGL-1 Compromise Causes Enlarged Lipid Droplets in C. elegans Dauer Larvae.

Meng Xie (501184)
Richard Roy (652797)

June 2015

(A)-(F) Disruption of ATGL-1, but not HSL function in both control daf-2(A),...

A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans

Shiwei Li
Shibin Xu
Yanli Ma
Shuang Wu
Yu Feng
Qingpo Cui
Lifeng Chen
Shuang Zhou
Yuanyuan Kong
Xiaoyu Zhang
Jialei Yu
Mengdi Wu
Shaobing O. Zhang

August 2016

To identify genes that regulate the dynamics of lipid droplet (LD) size, we have used the geneticall...

Lipid levels and distribution are altered in pry-1(mu38) mutants.

Ayush Ranawade (5942681)
Avijit Mallick (5942684)
Bhagwati P. Gupta (213804)

November 2018

Arrowheads indicate intestine and dotted areas gonad. (A) Representative DIC images of N2 and pry-1(...

Among three TBP family members in Drosophila, only TRF2 specifically regulates LD size.

Wei Fan (109074)
Sin Man Lam (200854)
Jingxue Xin (3820891)
Xiao Yang (19898)
Zhonghua Liu (148625)
Yuan Liu (88411)
Yong Wang (12837)
Guanghou Shui (136742)
Xun Huang (163341)

March 2017

(A) Knockdown of trf2 in larval fat body leads to increased LD size whereas knockdown of <...

Lipid droplet size is reduced in <i>Rab32/ltd</i> and <i>Rab32 GEF/ca</i> mutants.

Abstract

Extracted data

Lipid droplet size is reduced in <i>Rab32/ltd</i> and <i>Rab32 GEF/ca</i> mutants.

Abstract

Extracted data

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