Simulation of the SCN composed of two regions in DD and LD conditions.

<p>Simulation of the SCN with different architectures for the VL and DM regions (an coupled to an network, see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002419#pcbi.1002419.s007" target="_blank">Fig. S7</a> for a sketch of the topology), where the coupling constant between the DM cells is 0.15 and the DM cells are oscillating faster (see <i><a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002419#s4" target="_blank">Models</a></i>). (A–B) Phase difference of the cells in DD (A) and LD (B) conditions. Dots represent cells of the VL (beige region), whereas DM cells are small squares (light yellow region). Phase difference is color encoded: green corresponds to a phase delay, blue to a phase advance and red to antiphase (see also <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002419#pcbi.1002419.s013" target="_blank">Fig. S13</a>). (C–D) Concentration of in the individual VL (cyan lines) and DM cells (magenta lines), as well as the average over the VL cells (thick blue line), the DM cells (bold red line), and over the entire SCN (thick black line) in DD (C) and LD (D) conditions.