Effects of entrainment perturbations on the SCN composed of two regions.

<p>(A) Effect of a 4-hour interruption of the light entrainment during the day (see arrow a ) on VL (blue) and DM (red) average concentrations in the same SCN network as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002419#pcbi-1002419-g008" target="_blank">figure 8</a>. Dashed lines represent the unperturbed trajectories. (B) Effect of an 8-hour jet lag (long night, see arrow at ) on VL (blue), DM (red) average concentrations (same network). Dashed lines represent the unperturbed trajectory shifted from 8 hours. (C–D) Average concentration of at the extremum (points) of oscillations after an interruption of the light entrainment of 4 hours during the day (C), corresponding to panel A, or after a jet lag of 8 hours equivalent to a long night (D), corresponding to panel B. The average of VL cells is in blue and of DM cells in red. Dashed lines show unperturbed values. (E–F) Phase shift of the peak of for the VL (blue) and DM (red) after an interruption of the light entrainment of 4 hours during the day (E), corresponding to panel A, or after a jet lag of 8 hours equivalent to a long night (F), corresponding to panel B. A positive value corresponds to a phase advance.