Treatment with anti-αvβ5 antibody reverses the effect of uPA-silencing.

<p>HCFs were transfected with uPA siRNA and seeded with a blocking αvβ5 antibody or matched IgG. After 24 hours (A) cells were immunostained with anti-α-SMA antibody. Bar = 10 um. Images are from two independent experiments. (B) Metamorph analysis quantified changes in average cell size in each condition. ***p value<0.001. N = 3 for each experiment.