Primary dose-response profile of representative hits from each chemical series.

<p># Hits are compounds in series with activity <5 µM against the respective NMT. LHR = Local hit rate @ 0.4 similarity to indicate the proportion of similar compounds with activity in the primary screen. IC50 data are the mean of 3 separate experiments (in µM). These data were used to calculate ligand efficiency (LE) for each compound against their target NMT, and to derive selectivity (Sel) values for the primary screening targets.