Plot of dose-response activity against <i>Ldon</i> vs. <i>Hs</i>1 NMTs for primary screening hit and analogue screening set.

<p>In contrast to <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001625#pntd-0001625-g006" target="_blank">Figure 6</a>, a plot of potency against <i>Ldon</i> and <i>Hs</i>1 NMTs showed that activity did not correlate. Excellent selectivity was observed for several chemical series. The structures of representative members of four series are given in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001625#pntd-0001625-g005" target="_blank">Figure 5</a>.