Ligand efficiencies of confirmed SPR hits.
- Karin Regnström (5655538)
- Jiangli Yan (431258)
- Lan Nguyen (431259)
- Kari Callaway (337768)
- Yanli Yang (290019)
- Linnea Diep (431260)
- Weimei Xing (431261)
- Anirban Adhikari (431262)
- Paul Beroza (431263)
- Roy K. Hom (431264)
- Brigit Riley (431265)
- Don Rudolph (431266)
- Michael F. Jobling (431267)
- Jeanne Baker (153141)
- Jennifer Johnston (153207)
- Andrei Konradi (431268)
- Michael P. Bova (431269)
- Rick D. Artis (431270)
Publication date
July 2013
DOIAbstract
<p>Plot of ligand efficiencies (LE) of SPR confirmed hits vs. number of heavy atoms <i>N<sub>h.</sub></i> Binding affinities (K<sub>D</sub>) were obtained from injection of fragments in dose response manner from 50 uM in two-fold dilutions. One very interesting hit with LE of 0.5 and <i>HAC</i> of 13 is A (red dot) with a mid micro-molar affinity (K<sub>D</sub> of 18.6 uM).</p
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