Effects of the treatment with a TGF-β neutralizing antibody on the extracellular matrix remodeling induced by pressure overload in male mice.

<p>Myocardial transcript levels of <b>A</b>: Collagen I (Col I); <b>B</b>: Collagen III (Col III) and <b>C</b>: Fibronectin 1 (FN); in male mice sham operated or subjected to aortic arch constriction (TAC) and treated either with IgG1 or with a neutralizing antibody that recognizes all the isoforms of TGF-β (TGFβ-Ab). Data are expressed as the mean ± SEM. *p<0.05, **p<0.01 versus Sham; #p<0.05 versus TAC+TGFβ-Ab (ANOVA and Bonferroni post-hoc test). <b>D</b>: Representative histological sections illustrating myocardial fibrosis in the interventricular septum region stained in blue by Massons'trichrome (50×).