Characterization of myocardial tissue in wild type (WT) and TGF-β₁ transgenic mice (TGF-β₁) that have been treated with either metoprolol (METO), telmisartan (TELMI), or soluble TGF-βR-Fc (sR-Fc).

<p>(<b>A</b>) Myocardial TGF-β₁ protein expression as determined by Western blotting in heart homogenates from the various groups as indicated. RasGAP served as lysate control. (<b>B</b>) Body weight, heart weight, and heart/body weight ratio (n = 30–57 animals in each group). (<b>C–F</b>) Morphometric analysis of myocardial tissue (n = 5–9 animals in each group). Shown are the fractional areas of connective tissue (<b>C</b>), cardiac fibroblasts (<b>D</b>), cardiac myocytes (<b>E</b>), and cardiomyocyte diameter (<b>F</b>). *<i>p</i><0.05 vs. WT, ^#<i>p</i><0.05 vs. untreated TGF-β₁ mice.