Molecular subtypes compared by DNA methylation.
- Matthew D. Wilkerson (165493)
- Xiaoying Yin (165499)
- Vonn Walter (165501)
- Ni Zhao (165503)
- Christopher R. Cabanski (165505)
- Michele C. Hayward (165508)
- C. Ryan Miller (165511)
- Mark A. Socinski (165514)
- Alden M. Parsons (165518)
- Leigh B. Thorne (165521)
- Benjamin E. Haithcock (165525)
- Nirmal K. Veeramachaneni (165528)
- William K. Funkhouser (165532)
- Scott H. Randell (165539)
- Philip S. Bernard (165545)
- Charles M. Perou (109977)
- D. Neil Hayes (165551)
Publication date
May 2012
DOIAbstract
<p>Genomewide DNA methylation among the three LAD subtypes were compared by a Kruskal-Wallis test (two-sided <i>P</i>) in all cohorts with methylation (UNC <i>n</i> = 33) (A). Normal lung specimens are shown for reference. Regional variation in DNA methylation is displayed (B). For each chromosome arm, the proportion of sites hypermethylated in a subtype with respect to normal lung is plotted. Chromosome arms with at least 4 methylation sites are displayed. Tumors' DNA methylation and DNA copy number values for chromosome 5 p are displayed (C).</p
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