<p>(A) DNA methylation of all AML patients and all NBMs were categorized into 5 groups of methylation. There was no significant difference in the global DNA methylation between AML and NBM. (B) DNA methylation scores of all AMLs (blue line) and all NBMs (green line) were plotted against their density (frequency). AML has less frequency of DNA methylation scores>0.8 in the comparison with NBM. (C–J) Percentages of different groups of DNA methylation in the average of each triplicate of AML subtype and in the average of 4 NBMs. SINEs showed the highest difference in the DNA methylation scores>0.8 between NBM and AML.</p
<p>Comparison of average DNA methylation levels between AC tumor, AC normal (histologically normal l...
Background: Aberrant promoter DNA methylation has been shown to play a role in acute myeloid leukemi...
We attempted to define target genes that were inactivated in acute myeloid leukemia (AML) by DNA met...
<p>(A–F) For a single AML patient we categorized the gene methylation into 4 groups (>0.4, 0.4–0.6, ...
<p>(A) Unsupervised analysis of DNA methylation by ERRBS using hierarchical clustering (distance = 1...
SummaryWe hypothesized that DNA methylation distributes into specific patterns in cancer cells, whic...
Abstract: We hypothesized that DNA methylation distributes into specific patterns in cancer cells, ...
<p>(A) Venn diagram representing differentially methylated CpGs identified for IDH-mut and MLLr AMLs...
<div><p>Aberrant DNA methylation is known to occur in cancer, including hematological malignancies s...
<p>Genomewide DNA methylation among the three LAD subtypes were compared by a Kruskal-Wallis test (t...
International audienceCytogenetically normal acute myeloid leukemia (CN-AML) compose between 40% and...
Background: Epigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the ...
DNA methylation is a key epigenetic modification which, in mammals, occurs mainly at CpG dinucleotid...
Patterns of DNA methylation are substantially altered in malignancies compared to normal tissue, wit...
DNA methylation is a well-established epigenetic mechanism regulating gene expression. It has essent...
<p>Comparison of average DNA methylation levels between AC tumor, AC normal (histologically normal l...
Background: Aberrant promoter DNA methylation has been shown to play a role in acute myeloid leukemi...
We attempted to define target genes that were inactivated in acute myeloid leukemia (AML) by DNA met...
<p>(A–F) For a single AML patient we categorized the gene methylation into 4 groups (>0.4, 0.4–0.6, ...
<p>(A) Unsupervised analysis of DNA methylation by ERRBS using hierarchical clustering (distance = 1...
SummaryWe hypothesized that DNA methylation distributes into specific patterns in cancer cells, whic...
Abstract: We hypothesized that DNA methylation distributes into specific patterns in cancer cells, ...
<p>(A) Venn diagram representing differentially methylated CpGs identified for IDH-mut and MLLr AMLs...
<div><p>Aberrant DNA methylation is known to occur in cancer, including hematological malignancies s...
<p>Genomewide DNA methylation among the three LAD subtypes were compared by a Kruskal-Wallis test (t...
International audienceCytogenetically normal acute myeloid leukemia (CN-AML) compose between 40% and...
Background: Epigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the ...
DNA methylation is a key epigenetic modification which, in mammals, occurs mainly at CpG dinucleotid...
Patterns of DNA methylation are substantially altered in malignancies compared to normal tissue, wit...
DNA methylation is a well-established epigenetic mechanism regulating gene expression. It has essent...
<p>Comparison of average DNA methylation levels between AC tumor, AC normal (histologically normal l...
Background: Aberrant promoter DNA methylation has been shown to play a role in acute myeloid leukemi...
We attempted to define target genes that were inactivated in acute myeloid leukemia (AML) by DNA met...