<p>(A) Representative ON-gating current recordings from Kv2.1 and Kv2.1/Kv6.4 channels. (B) Boltzmann fits of Q–V curves for Kv2.1 alone (circle) and upon co-expression with Kv6.4 (triangle). (C) Voltage-dependence of the weighted time constants of <i>I</i><sub>Q</sub> of Kv2.1 alone (circle) and upon co-expression with Kv6.4 (triangle). <i>I</i><sub>Q</sub> kinetics was obtained by fitting the <i>I</i><sub>Q</sub> decay from the current recordings shown in panel c. (C) Scaled up view of <i>I</i><sub>Q</sub> currents at different voltages for Kv2.1 alone (left) and upon co-expression with Kv6.4 (right). The inset highlight the crossing at −50 mV observed for Kv2.1/Kv6.4 channels.</p
<p>(A) and (B) Representative current traces of WT and A226W, respectively. From a holding potential...
<p>Channel kinetics were compared between Kv11.1-wt and Kv11.1-wt+Kv11.1-mut groups as no appreciabl...
<p>(A) Whole-cell current traces from representative experiments of WT-Q1077del and S1787N/Q1077del ...
<p>V<sub>50</sub> (half activation voltage) and z (equivalent gating charge) were derived from fitti...
<p>A. Typical families of current traces recorded at 37°C from Kv11.1-1A (left) and Kv11.1-3.1 (righ...
<p>For comparison the Kv2.1 parameters are shown under “2<sup>nd</sup> component” when two component...
<p>V<sub>50</sub> (half activation voltage) and z (equivalent gating charge) were derived from fitti...
<p><b>A</b>, illustrates half-activation voltages (V<sub>50</sub>) of currents resulting from expres...
<p>The midpoints of inactivation (<i>V<sub>1/2</sub></i>) and slope factors (<i>k</i>) were obtained...
<p><b><i>(a)</i></b> Comparison of inactivation time course in NvShak1, NvShak4 and NvShak5 currents...
<p>Representative currents recording from HEK293T cells transfected with WT-, Del6- or Del2-Kv7.2, a...
<p>Biophysical properties of Kv4.2+KChIP3a+DPP6a currents were compared before (black symbols) and a...
<p>(A) Representative ionic currents of Kv2.1 homotetramers (middle) and Kv2.1/Kv6.4 heterotetramers...
The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitabl...
<p>(A) Normalised <i>I</i><sub>Kv6.1</sub> current trace in simulated voltage-clamp experiments. Cur...
<p>(A) and (B) Representative current traces of WT and A226W, respectively. From a holding potential...
<p>Channel kinetics were compared between Kv11.1-wt and Kv11.1-wt+Kv11.1-mut groups as no appreciabl...
<p>(A) Whole-cell current traces from representative experiments of WT-Q1077del and S1787N/Q1077del ...
<p>V<sub>50</sub> (half activation voltage) and z (equivalent gating charge) were derived from fitti...
<p>A. Typical families of current traces recorded at 37°C from Kv11.1-1A (left) and Kv11.1-3.1 (righ...
<p>For comparison the Kv2.1 parameters are shown under “2<sup>nd</sup> component” when two component...
<p>V<sub>50</sub> (half activation voltage) and z (equivalent gating charge) were derived from fitti...
<p><b>A</b>, illustrates half-activation voltages (V<sub>50</sub>) of currents resulting from expres...
<p>The midpoints of inactivation (<i>V<sub>1/2</sub></i>) and slope factors (<i>k</i>) were obtained...
<p><b><i>(a)</i></b> Comparison of inactivation time course in NvShak1, NvShak4 and NvShak5 currents...
<p>Representative currents recording from HEK293T cells transfected with WT-, Del6- or Del2-Kv7.2, a...
<p>Biophysical properties of Kv4.2+KChIP3a+DPP6a currents were compared before (black symbols) and a...
<p>(A) Representative ionic currents of Kv2.1 homotetramers (middle) and Kv2.1/Kv6.4 heterotetramers...
The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitabl...
<p>(A) Normalised <i>I</i><sub>Kv6.1</sub> current trace in simulated voltage-clamp experiments. Cur...
<p>(A) and (B) Representative current traces of WT and A226W, respectively. From a holding potential...
<p>Channel kinetics were compared between Kv11.1-wt and Kv11.1-wt+Kv11.1-mut groups as no appreciabl...
<p>(A) Whole-cell current traces from representative experiments of WT-Q1077del and S1787N/Q1077del ...