Survival and weight loss in IFNAR^−/− mice.

<p>(<b>A</b>) <b>High dose (10³ ffu and 10⁴ ffu) infection.</b> IFNAR^−/− mice (n = 5–10) were infected via the intra-peritoneal route with either 10³ ffu or 10⁴ ffu per animal of recombinant (rZEBOV and rREBOV) or chimeric (rZEBOV-RGP and rREBOV-ZGP) Ebola viruses. Mouse-adapted ZEBOV (MA-ZEBOV) and wild-type Ebola viruses (wt-ZEBOV and wt-REBOV) served as controls. Animals were monitored for 14 days for survival (upper panel) and weight loss (lower panel) and observed for an additional 14 days to ensure no additional mortality occurred. Weights are shown as the mean values for each group along with bars indicating standard error values. (<b>B</b>) <b>Low dose (10 ffu) infection.</b> IFNAR^−/− mice (n = 10–15) were infected and monitored as indicated above, except that a dose of 10 ffu per animal was given.