Histomorphometric measurement of bone formation and bone resorption following intermittent PTH in WT and Ts65Dn mice.
- Tristan W. Fowler (143286)
- Kent D. McKelvey (143289)
- Nisreen S. Akel (143294)
- Jaclyn Vander Schilden (143297)
- Anthony W. Bacon (143302)
- John W. Bracey (143309)
- Timothy Sowder (143314)
- Robert A. Skinner (143319)
- Frances L. Swain (143324)
- William R. Hogue (143331)
- Donna B. Leblanc (143335)
- Dana Gaddy (143341)
- Galen R. Wenger (143344)
- Larry J. Suva (143349)
Publication date
August 2012
DOIAbstract
<p>Male mice (N = 6–8 per group) were given daily injections of vehicle or 30 or 80 ug/kg PTH(1–34) for 4 weeks. (<b>A</b>) Mineral apposition rate (MAR) (um<sup>3</sup>/um<sup>2</sup>/day), (<b>B</b>) Bone formation rate/bone surface (BFR/BS) (um<sup>3</sup>/um<sup>2</sup>/day), (<b>C</b>) Number of osteoblasts/bone perimeter (N.Ob./B.Pm), (<b>D</b>) Number of osteoclasts/bone perimeter (N.Oc./B.Pm.) were measured in WT and Ts65Dn mice vehicle or PTH treated (30 or 80 ug/kg/day) (open bars, WT; closed bars, Ts65Dn). *, p<0.05 vs. respective vehicle control; #, p<0.05 vs. WT vehicle.</p
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