NSG mice develop GvHD at a faster rate than BRG mice.

<p>10⁷ freshly isolated human PBMCs were injected intravenously via the tail vein into adult 6–10 week old NSG and BRG immunodeficient mice. (A) Survival of NSG mice [median survival time (MST) = 40 days, <i>n</i> = 12, 4 PBMC donors] was significantly shorter than that of BRG mice (MST = 71, <i>n</i> = 10, 3 PBMC donors). (B) The average weight is shown as a percentage of starting weight. (A) Log-rank Mantel-Cox Test and (B) unpaired t test. Each data point represents the mean ±SEM.