Expression patterns of apoptosis genes mutually altered by both rotenone doses.

<p>The expression levels of 52 apoptosis associated genes that were mutually and mostly similarly changed by both doses at 4 weeks are shown as fold changes relative to vehicle-treated cells. The expression patterns observed at 1 week (<b>A</b>) and at 4 weeks (<b>B</b>) of rotenone exposure are shown. The classification of each gene, according to their effect on apoptosis, as anti-apoptotic (−), pro-apoptotic (+), and ambivalent (+−) is indicated immediately after the listed symbol of each gene; followed by a further classification, based on the detected genes changes, into pro-survival events (indicated by s, to designate upregulation of anti-apoptotic genes and the downregulation of pro-apoptotic genes) and pro-death events (indicated by d, to designate upregulation of pro-apoptotic and the downregulation anti-apoptotic genes). Genes differentially changed by both doses are classified as both <i>s</i> and <i>d</i>; and ambivalent genes (+−) cannot be classified by these parameters. The 1-fold change level is indicated by dotted line.