Streamlined illustration of the effects of rotenone on apoptosis and proliferation across time.

<p>(<b>A</b>) Rotenone-induced expression changes in apoptosis-associated genes, classified as pro-survival or pro-death events as defined in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044700#pone-0044700-g004" target="_blank"><b>Figs. 4</b></a><b>& </b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044700#pone-0044700-g005" target="_blank"><b>5</b></a>, at 1 week and 4 weeks were counted and plotted to reductively illustrate apoptotic differences between doses across time. (<b>B</b>) Rotenone-induced expression changes in cell proliferation-associated genes, classified as stimulatory (+) or inhibitory (−) events based on the assumption that increased negative regulators and decreased positive regulators of proliferation are inhibitory events and conversely, increased positive regulators and decreased negative regulators are stimulatory events were tallied and plotted to reductively illustrate proliferation difference between doses across time.